Molecules, Free Full-Text

Positive-sense single-stranded RNA (+RNA) viruses have proven to be important pathogens that are able to threaten and deeply damage modern societies, as illustrated by the ongoing COVID-19 pandemic. Therefore, compounds active against most or many +RNA viruses are urgently needed. Here, we present PR673, a helquat-like compound that is able to inhibit the replication of SARS-CoV-2 and tick-borne encephalitis virus in cell culture. Using in vitro polymerase assays, we demonstrate that PR673 inhibits RNA synthesis by viral RNA-dependent RNA polymerases (RdRps). Our results illustrate that the development of broad-spectrum non-nucleoside inhibitors of RdRps is feasible.

scientific background with molecules or atoms Abstract structure

Molecules, Free Full-Text

Effects of zwitterionic molecules on ionic association in ethylene

Molecules An Open Access Journal from MDPI

Correlation of low expression of hMOF with clinicopathological

Molecules An Open Access Journal from MDPI

Molecules of murder : criminal molecules and classic cases

Molecules An Open Access Journal from MDPI

Clinical and Translational Medicine - Wiley Online Library