GPC2-CAR T cells tuned for low antigen density mediate potent

Pediatric cancers often mimic fetal tissues and express proteins normally silenced postnatally that could serve as immune targets. We developed T cell…

Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting

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A chimeric antigen receptor uniquely recognizing MICA/B stress proteins provides an effective approach to target solid tumors - ScienceDirect

Preclinical development of a chimeric antigen receptor T cell therapy targeting FGFR4 in rhabdomyosarcoma - ScienceDirect

Antitumor activity without on-target off-tumor toxicity of GD2–chimeric antigen receptor T cells in patients with neuroblastoma

GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity - ScienceDirect

Mechanisms and strategies for safe chimeric antigen receptor T‐cell activity control - Stock - 2023 - International Journal of Cancer - Wiley Online Library

PDF) Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma

Full article: B7-H3-targeted CAR-T cell therapy for solid tumors

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Mechanisms of Resistance and Treatment of Relapse after CAR T-cell Therapy for Large B-cell Lymphoma and Multiple Myeloma - Transplantation and Cellular Therapy, Official Publication of the American Society for Transplantation and