Replicatively senescent cells are arrested in G1 and G2 phases - Figure F1

Senescent human fibroblast cultures contain a large fraction of putative G2-arrested cells with 4N DNA content. (A) Propidium iodide (PI) staining and flow cyctometric analysis of HCA2 normal human foreskin fibroblasts. Cells entered senescence at PD73. (B) PI staining of replicatively senescent human lung fibroblasts WI-38, and IMR-90 at PDs 73 and 68 respectively. (C) The fraction of 4N cells in senescent cell population does not diminish with time. Replicatively senescent HCA2 cells were analyzed by PI staining at weekly intervals for 10 weeks stating from the onset of senescence.

TGF-β induces corneal endothelial senescence via increase of

Frontiers Reversed Senescence of Retinal Pigment Epithelial Cell

Releasing YAP dysfunction‐caused replicative toxicity rejuvenates

Full article: Senescence from G2 arrest, revisited

Senescent BT-20 cells with PRL-3 knockdown arrest in G1 despite

Distinct Initiation and Maintenance Mechanisms Cooperate to Induce

Accelerated Senescence of Cancer Stem Cells: A Failure to Thrive

Cell cycle arrest is not senescence

Reciprocal regulation of p21 and Chk1 controls the Cyclin D1-RB

Cellular senescence in the aging and diseased kidney

Cellular senescence preserves viral genome maintenance

Frontiers Cinobufagin Induces Cell Cycle Arrest at the G2/M