Death in hospital following ICU discharge: insights from the LUNG SAFE study, Critical Care

Background To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward. Methods The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from 50 countries globally. This study aimed to understand the frequency and factors associated with death in hospital in patients who survived their ICU stay. We examined outcomes in the subpopulation discharged with no limitations of life sustaining treatments (‘treatment limitations’), and the subpopulations with treatment limitations. Results 2186 (94%) patients with no treatment limitations discharged from ICU survived, while 142 (6%) died in hospital. 118 (61%) of patients with treatment limitations survived while 77 (39%) patients died in hospital. Patients without treatment limitations that died in hospital after ICU discharge were older, more likely to have COPD, immunocompromise or chronic renal failure, less likely to have trauma as a risk factor for ARDS. Patients that died post ICU discharge were less likely to receive neuromuscular blockade, or to receive any adjunctive measure, and had a higher pre- ICU discharge non-pulmonary SOFA score. A similar pattern was seen in patients with treatment limitations that died in hospital following ICU discharge. Conclusions A significant proportion of patients die in hospital following discharge from ICU, with higher mortality in patients with limitations of life-sustaining treatments in place. Non-survivors had higher systemic illness severity scores at ICU discharge than survivors. Trial Registration: ClinicalTrials.gov NCT02010073 .

JCM, Free Full-Text

ARDS: Deep Dive into the Evidence EMRA

Follow-up after critical care – topic of research paper in Health sciences. Download scholarly article PDF and read for free on CyberLeninka open science hub.

Life, Free Full-Text

Outcomes after Critical Illness

COVID-19 therapeutics: Challenges and directions for the future

RT education and COVID-19 pneumonia discharge quality Published in Canadian Journal of Respiratory Therapy

Outcomes after Critical Illness

European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care

Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit

Postconditioning effects following sevoflurane inhalational sedation in the ICU: a pilot study in cardiac surgery patients – topic of research paper in Health sciences. Download scholarly article PDF and read for free

Prone positioning for patients intubated for severe acute respiratory distress syndrome (ARDS) secondary to COVID-19: a retrospective observational cohort study - British Journal of Anaesthesia

Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation

PDF) The Impact of Step-Down Unit Care on Patient Outcomes After ICU Discharge

ARDS: Deep Dive into the Evidence EMRA